(R)-LMI | Probechem Biochemicals

Chemical Structure : (R)-LMI

(R)-LMI (H2N-R-Leu-Met-Ile-COOH)

Catalog No.: PC-38308Not For Human Use, Lab Use Only.

(R)-LMI (H2N-R-Leu-Met-Ile-COOH) is a tripeptide analogue of corticotropin-releasing factor (CRF) and CRF antagonist targeting the N-domain of CRF1 receptor.

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Biological Activity

(R)-LMI (H2N-R-Leu-Met-Ile-COOH) is a tripeptide analogue of corticotropin-releasing factor (CRF) and CRF antagonist targeting the N-domain of CRF1 receptor.
(R)-LMI inhibits CRF-stimulated cAMP accumulation with IC50 of 1.7 uM.
(R)-LMI inhibits the production of interleukins by adipocytes and the proliferation rate of RAW 264.7 cells.

Physicochemical Properties

M.Wt	375.53
Formula	C17H33N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	H2N-R-Leu-Met-Ile-COOH

References

1. George Liapakis, et al. Amino Acids. 2020 Sep;52(9):1337-1351.

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(R)-LMI (H2N-R-Leu-Met-Ile-COOH)

Biological Activity

Physicochemical Properties

References

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