(R)-OF-NB1

Chemical Structure : (R)-OF-NB1

Catalog No.: PC-21397Not For Human Use, Lab Use Only.

(R)-OF-NB1 is a small molecule splice variant GluN2B-selective NMDAR antagonist with IC50 of 675 nM and 97 nM for F-NB1 for splice variant containing exon 5 and GluN1-1a in X. laevis oocytes.

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Biological Activity

(R)-OF-NB1 is a small molecule splice variant GluN2B-selective NMDAR antagonist with IC50 of 675 nM and 97 nM for F-NB1 for splice variant containing exon 5 and GluN1-1a in X. laevis oocytes.
(R)-OF-NB1 clearly discriminates the two splice variants, GluN1-1a and GluN1-1b.

Physicochemical Properties

M.Wt	329.42
Formula	C20H24FNO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-(2-fluorophenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-1,7-diol

References

1. Ritter N, et al. Mol Neurobiol. 2023 Dec;60(12):7238-7252.

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(R)-OF-NB1

Biological Activity

Physicochemical Properties

References

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