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(R)-SW203668

Chemical Structure : (R)-SW203668

CAS No.: 1673558-51-4

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(R)-SW203668 ( (−)-SW203668, SCD inhibitor (R)-27)

Catalog No.: PC-20382Not For Human Use, Lab Use Only.

(R)-SW203668 (SCD inhibitor (R)-27) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=11 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-SW203668 (SCD inhibitor (R)-27) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=11 nM).
    (R)-SW203668 shows insensitive (e.g., H1155, IC50>5 uM) NSLCL cell lines.
    (R)-SW203668 shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P450 4F11.

    Physicochemical Properties

    M.Wt 389.47
    Formula C22H19N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(amino(phenyl)methyl)-N-(6-methoxybenzo[d]thiazol-2-yl)benzamide

    References

    1. Noelle S Williams, et al. J Med Chem. 2020 Sep 10;63(17):9773-9786.

    2. JM, et al. Nat Chem Biol. 2016 Apr;12(4):218-25.

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