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Chemical Structure : (R)-SW203668
Catalog No.: PC-20382Not For Human Use, Lab Use Only.
(R)-SW203668 (SCD inhibitor (R)-27) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=11 nM).
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(R)-SW203668 (SCD inhibitor (R)-27) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=11 nM).
(R)-SW203668 shows insensitive (e.g., H1155, IC50>5 uM) NSLCL cell lines.
(R)-SW203668 shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P450 4F11.
| M.Wt | 389.47 | |
| Formula | C22H19N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Noelle S Williams, et al. J Med Chem. 2020 Sep 10;63(17):9773-9786.
2. JM, et al. Nat Chem Biol. 2016 Apr;12(4):218-25.
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