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(R)-ZINC-3573

Chemical Structure : (R)-ZINC-3573

CAS No.: 2089389-15-9

(R)-ZINC-3573 (ZINC-72453573, ZINC-3573)

Catalog No.: PC-62227Not For Human Use, Lab Use Only.

(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

(R)-ZINC-3573 (ZINC-72453573) is a potent, MRGPRX2-selective small-molecule agonist with EC50 of 740 nM.
(R)-ZINC-3573 shows minimal agonist efficacy at receptors other than MRGPRX2 at 10 uM, as well as a panel of 97 representative human kinases.|
(R)-ZINC-3573 promoted degranulation in LAD2 mast cells.
(R)-ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

Physicochemical Properties

M.Wt 307.401
Formula C18H21N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-Dimethyl-[1-(5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl)-pyrrolidin-3-yl]-amine

References

1. Lansu K, et al. Nat Chem Biol. 2017 May;13(5):529-536.
2. Can Cao, et al. Nature. 2021 Dec;600(7887):170-175.

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