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(Rac)-JBJ-04-125-02

Chemical Structure : (Rac)-JBJ-04-125-02

CAS No.: 2140807-05-0

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(Rac)-JBJ-04-125-02 (JBJ-04-125-02)

Catalog No.: PC-72985Not For Human Use, Lab Use Only.

(Rac)-JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

(Rac)-JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.
JBJ-04-125-02 displays excellent selectivity against a panel of 468 kinases using the KINOMEscan approach (S-Score (35)=0.02).
JBJ-04-125-02 increases apoptosis and efficacy in vitro and in vivo compared with either single agent alone when combined with osimertinib.

Physicochemical Properties

M.Wt 543.617
Formula C29H26FN5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide

References

1. To C, et al. Cancer Discov. 2019 Jul;9(7):926-943.

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