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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Free Fatty Acid Receptor (FFAR)-(S)-4CMTB
(S)-4CMTB

Chemical Structure : (S)-4CMTB

CAS No.: 1103523-24-5

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(S)-4CMTB (Phenylacetamide 1;AMG-7703)

Catalog No.: PC-35696Not For Human Use, Lab Use Only.

(S)-4CMTB (AMG 7703, Phenylacetamide 1) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.7 and 0.96 uM for hFFA2 and mFFA2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (S)-4CMTB (AMG 7703, Phenylacetamide 1) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.7 and 0.96 uM for hFFA2 and mFFA2, respectively.
    Phenylacetamide 1 is inactive against a panel of GPCRs that included FFA1, FFA3, GPR109A, growth hormone secretagogue receptor, endothelin type B receptor, CCR2, CXCR3, CXCR4, and CCR7 at 30 uM.
    Phenylacetamide 1 is capable of activating both Gαq- and Gαi -coupled pathways for receptor function.
    Phenylacetamide 1 inhibits lipolysis in 3T3L1 adipocytes in a concentration-dependent manner as measured by the reduction of glycerol production in adipocytes.

    Physicochemical Properties

    M.Wt 294.797
    Formula C14H15ClN2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide

    References

    1. Taeweon Lee, et al. Mol Pharmacol. 2008 Dec;74(6):1599-609. 

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