(S)-4CMTB (S-4CMTB, AMG 7703) | FFA2 agonist

Chemical Structure : (S)-4CMTB

CAS No.: 1103523-24-5

(S)-4CMTB (S-4CMTB, Phenylacetamide 1, AMG7703)

Catalog No.: PC-35696Not For Human Use, Lab Use Only.

(S)-4CMTB (S-4CMTB, AMG 7703, Phenylacetamide 1) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.7 and 0.96 uM for hFFA2 and mFFA2, respectively.

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10 mg	$218	In stock
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Biological Activity

(S)-4CMTB (S-4CMTB, AMG 7703, Phenylacetamide 1) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.7 and 0.96 uM for hFFA2 and mFFA2, respectively.

Phenylacetamide 1 is inactive against a panel of GPCRs that included FFA1, FFA3, GPR109A, growth hormone secretagogue receptor, endothelin type B receptor, CCR2, CXCR3, CXCR4, and CCR7 at 30 uM.

Phenylacetamide 1 is capable of activating both Gαq- and Gαi -coupled pathways for receptor function.

Phenylacetamide 1 inhibits lipolysis in 3T3L1 adipocytes in a concentration-dependent manner as measured by the reduction of glycerol production in adipocytes.

Physicochemical Properties

M.Wt	294.797
Formula	C14H15ClN2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide

References

1. Taeweon Lee, et al. Mol Pharmacol. 2008 Dec;74(6):1599-609.

(S)-4CMTB (S-4CMTB, Phenylacetamide 1, AMG7703)

Biological Activity

Physicochemical Properties

References

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