(S)-V-0219

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Chemical Structure : (S)-V-0219

Catalog No.: PC-72854Not For Human Use, Lab Use Only.

(S)-(+)-V-0219 is an orally acitve, small molecule positive allosteric modulator (PAM) of GLP-1R.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

(S)-(+)-V-0219 is an orally acitve, small molecule positive allosteric modulator (PAM) of GLP-1R.
(S)-V-0219 exhibits enhanced efficacy of GLP-1R stimulation, subnanomolar potency in the potentiation of insulin secretion, and no significant off-target activities.
(S)-V-0219 shows a remarkable in vivo activity, reducing food intake and improving glucose handling in normal and diabetic rodents.

Physicochemical Properties

M.Wt	410.441
Formula	C20H25F3N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Morpholine, 4-[[(3S)-1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-3-piperidinyl]methyl]-

References

1. Juan M. Decara, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.1c01842

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(S)-V-0219

Biological Activity

Physicochemical Properties

References

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