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Chemical Structure : (S)-V-0219
Catalog No.: PC-72854Not For Human Use, Lab Use Only.
(S)-(+)-V-0219 is an orally acitve, small molecule positive allosteric modulator (PAM) of GLP-1R.
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(S)-(+)-V-0219 is an orally acitve, small molecule positive allosteric modulator (PAM) of GLP-1R.
(S)-V-0219 exhibits enhanced efficacy of GLP-1R stimulation, subnanomolar potency in the potentiation of insulin secretion, and no significant off-target activities.
(S)-V-0219 shows a remarkable in vivo activity, reducing food intake and improving glucose handling in normal and diabetic rodents.
| M.Wt | 410.441 | |
| Formula | C20H25F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Juan M. Decara, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.1c01842
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