(S)-dHTC1

Chemical Structure : (S)-dHTC1

Catalog No.: PC-25534Not For Human Use, Lab Use Only.

(S)-dHTC1 is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 49 nM for ENL.

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Biological Activity

(S)-dHTC1 is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 49 nM for ENL.

M.Wt	676.79
Formula	C33H40N8O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-cyclobutyl-2-(3-((2-(4-((6,8-dioxo-2,7-diazaspiro[4.4]nonane)-2-sulfonamido)piperidin-1-yl)ethyl)carbamoyl)phenyl)imidazo[1,2-a]pyridine-6-carboxamide

1. Shaum JB, et al. bioRxiv [Preprint]. 2025 Sep 4:2024.09.30.615685.