(S)-mepazine

Chemical Structure : (S)-mepazine

Catalog No.: PC-25812Not For Human Use, Lab Use Only.

(S)-mepazine is a potent, selective MALT1 paracaspase inhibitor with IC50 of 0.26 uM, has approximately 10-fold greater MALT1 inhibitory activity than (R)-mepazine.

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Biological Activity

(S)-mepazine is a potent, selective MALT1 paracaspase inhibitor with IC50 of 0.26 uM, has approximately 10-fold greater MALT1 inhibitory activity than (R)-mepazine.

Physicochemical Properties

M.Wt	310.46
Formula	C19H22N2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine

References

1. Di Pilato M, et al. J Immunother Precis Oncol. 2023 Mar 3;6(2):61-73.

2. Schlauderer F, et al. Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase. Angew Chem Int Ed Engl . 2013;52:10384–10387.

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(S)-mepazine

Biological Activity

Physicochemical Properties

References

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