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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-iGluR-(S)93-31
(S)93-31

Chemical Structure : (S)93-31

CAS No.: 457897-98-2

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(S)93-31 ((S) 93-31)

Catalog No.: PC-61239Not For Human Use, Lab Use Only.

(S)93-31 is a pH-dependent, GluN2B-selective inhibitor of NMDA receptor with IC50 of 0.19 uM at pH6.9, 10-fold selecivity over brain tissue pH 7.6 (IC50=1.8 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (S)93-31 is a pH-dependent, GluN2B-selective inhibitor of NMDA receptor with IC50 of 0.19 uM at pH6.9, 10-fold selecivity over brain tissue pH 7.6 (IC50=1.8 uM).
    (S)93-31 maximizes neuroprotection in ischemic tissue while minimizing on-target side effects associated with NMDAR blockade in noninjured brain regions.

    Physicochemical Properties

    M.Wt 489.452
    Formula C22H30Cl2N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide

    References

    1. Yuan H, et al. Neuron. 2015 Mar 18;85(6):1305-1318.

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