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(α4)3(β2)2 nAChR PAM CMPI

Chemical Structure : (α4)3(β2)2 nAChR PAM CMPI

CAS No.: 1076223-85-2

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(α4)3(β2)2 nAChR PAM CMPI

Catalog No.: PC-23918Not For Human Use, Lab Use Only.

CMPI is a subtype-selective positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs), preferentially potentiates the (α4)3(β2)2 nAChR with EC50 of 0.26 uM, but not (α4)2(β2)3 nAChR isoforms.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CMPI is a subtype-selective positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs), preferentially potentiates the (α4)3(β2)2 nAChR with EC50 of 0.26 uM, but not (α4)2(β2)3 nAChR isoforms.

Physicochemical Properties

M.Wt 342.83
Formula C18H19ClN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole

References

1. Wang ZJ, et al. J Biol Chem. 2017 Jun 16;292(24):9988-10001.

2. Hamouda AK, et al. Mol Pharmacol. 2016 May;89(5):575-84.

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