(α4)3(β2)2 nAChR PAM CMPI

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Chemical Structure : (α4)3(β2)2 nAChR PAM CMPI

Catalog No.: PC-23918Not For Human Use, Lab Use Only.

CMPI is a subtype-selective positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs), preferentially potentiates the (α4)3(β2)2 nAChR with EC50 of 0.26 uM, but not (α4)2(β2)3 nAChR isoforms.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	342.83
Formula	C18H19ClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole

References

1. Wang ZJ, et al. J Biol Chem. 2017 Jun 16;292(24):9988-10001.

2. Hamouda AK, et al. Mol Pharmacol. 2016 May;89(5):575-84.

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