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1-NM-PP1

Chemical Structure : 1-NM-PP1

CAS No.: 221244-14-0

1-NM-PP1 (1NM-PP1)

Catalog No.: PC-26293Not For Human Use, Lab Use Only.

1-NM-PP1 is a cell-permeable PP1 analog and potent Src family kinases inhibitor with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively, also inhibits PKD with IC50 of 398 nM (PKD2) and analog-sensitive CRK9 (CRK9AS).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

1-NM-PP1 is a cell-permeable PP1 analog and potent Src family kinases inhibitor with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively, also inhibits PKD with IC50 of 398 nM (PKD2) and analog-sensitive CRK9 (CRK9AS).

Physicochemical Properties

M.Wt 331.42
Formula C20H21N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(tert-butyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

References

1. Goyard S, et al. Mol Biol Cell. 2008 May;19(5):2251-66.

2. Plank M, et al. Mol Biol Cell. 2024 Apr 1;35(4):ar60.

3. Bishop AC, et al. Nature. 2000 Sep 21;407(6802):395-401.

4. Gosavi U, et al. Mol Microbiol. 2020 Jun;113(6):1225-1239.

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