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1-Naphthyl PP1 hydrochloride

Chemical Structure : 1-Naphthyl PP1 hydrochloride

CAS No.: 956025-47-1

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1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride)

Catalog No.: PC-43793Not For Human Use, Lab Use Only.

A potent Src family kinases with IC50 of 1.0/0.6/0.6 uM for v-Sr/c-Fyn/c-Abl.

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10 mg $105.6 In stock
50 mg $424.8 In stock
100 mg $720 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent Src family kinases with IC50 of 1.0/0.6/0.6 uM for v-Sr/c-Fyn/c-Abl; less potent for CDK2 and CaMK II; also inhibits Kin28 and Srb10 kinases; potently blocks prostate cancer cell proliferation by inducing G2/M arrest.

Physicochemical Properties

M.Wt 353.8486
Formula C19H20ClN5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 73 mg/mL
Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-, hydrochloride (1:1)

References

1. Bishop AC, et al. Nature. 2000 Sep 21;407(6802):395-401.

2. Kanin EI, et al. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5812-7.

3. Liu Y, et al. Mol Cell Biol. 2004 Feb;24(4):1721-35.

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