Chemical Structure : 10-F05
CAS No.:
1375471-68-3
10-F05
Catalog No.: PC-24338Not For Human Use, Lab Use Only.
10-F05 is a covalent small molecule inhibitor of bacterial β-ketoacyl-acyl carrier protein synthase III (FabH) and MiaA tRNA prenyltransferase, demonstrates broad-spectrum antibacterial effectiveness (MIC=2.5 uM, S. flexneri).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
10-F05 is a covalent small molecule inhibitor of bacterial β-ketoacyl-acyl carrier protein synthase III (FabH) and MiaA tRNA prenyltransferase, demonstrates broad-spectrum antibacterial effectiveness (MIC=2.5 uM, S. flexneri).
10-F05 is effective against multiple ESKAPE pathogens and demonstrates a slow resistance development.
10-F05 exhibits low cytotoxicity in HEK293T cells.
10-F05 specifically reacts with MiaA Cys273, disrupts MiaA and tRNA substrate binding.
10-F05 reduces translation fidelity and stress resistance through MiaA inhibition.
Physicochemical Properties
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M.Wt
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239.63
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Formula
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C10H7ClFN3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-chloro-1-(1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one
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References
1. Jin Y, et al. Cell Chem Biol. 2025 Mar 20;32(3):434-448.e9.
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