14-3-3-ERα stabilizer 181 | CAS 3057296-86-0

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Chemical Structure : 14-3-3-ERα stabilizer 181

14-3-3-ERα stabilizer 181 (14-3-3-ERα stabilizer)

Catalog No.: PC-25263Not For Human Use, Lab Use Only.

14-3-3/ERα stabilizer 181 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (appKD of 18 nM, 116-fold stabilization at 100 μM compound).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	496.47
Formula	C25H35Cl2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-1-(9-(4-((4-chlorophenyl)amino)-2,6-dimethyltetrahydro-2H-pyran-4-carbonyl)-3,9-diazaspiro[5.5]undecan-3-yl)ethan-1-one

References

1. Konstantinidou M, et al. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343.

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14-3-3-ERα stabilizer 181 (14-3-3-ERα stabilizer)

Biological Activity

Physicochemical Properties

References

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