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Chemical Structure : 14-3-3σ/ERα stabilizer 181
Catalog No.: PC-21138Not For Human Use, Lab Use Only.
14-3-3σ/ERα stabilizer 181 is a selective and highly potent covalent stabilizer of 14-3-3σ/ERα PPI complex with EC50 of 1 uM.
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14-3-3σ/ERα stabilizer 181 is a selective and highly potent covalent stabilizer of 14-3-3σ/ERα PPI complex with EC50 of 1 uM.
14-3-3σ/ERα stabilizer 181 shows remarkable selectivity for 14-3-3σ/ERα (appKD of 18 nM), with a similar selectivity profile as Fusicoccin-A (Cat# PC-61233).
14-3-3σ/ERα stabilizer 181 shows no stabilization of 14-3-3σ/C-RAF, SOS1, ChREBP, p65 and PIN1, up to 150 μM.
14-3-3σ/ERα stabilizer 181 shows a comparable stabilization profile as Fusicoccin-A.
| M.Wt | 496.47 | |
| Formula | C25H35Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Konstantinidou M, et al. J Am Chem Soc. 2023 Sep 7. doi: 10.1021/jacs.3c05161.
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