Chemical Structure : 19MS-5
CAS No.:
1465291-19-3
19MS-5
Catalog No.: PC-25299Not For Human Use, Lab Use Only.
19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays.
19MS-5 effectively inhibits CD28:B7-1 (CD80) interactions with IC50 of 7.83uM in ELISA-based inhibition assays.
19MS-5 inhibits T cell activation markers in tumor–PBMC co-culture, suppresses CD28-dependent cyto-kine release, including IFN-γ, IL-2, and TNF-α, indicative of strong CD28-mediated T cell activation.
Physicochemical Properties
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M.Wt
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315.33
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Formula
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C16H17N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl 3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate
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References
1. Upadhyay S, et al. bioRxiv [Preprint]. 2025 Aug 2:2025.07.31.667814.
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