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Chemical Structure : 1E7-03
Catalog No.: PC-35229Not For Human Use, Lab Use Only.
1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).
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1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46.
| M.Wt | 503.555 | |
| Formula | C28H29N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carey BD, et al. J Virol. 2018 May 16. pii: JVI.02068-17.
2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38.
3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75.
4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769.
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