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Chemical Structure : 2-12-2-deg
Catalog No.: PC-22558Not For Human Use, Lab Use Only.
2-12-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.21 uM, Dmax of 95%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
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2-12-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.21 uM, Dmax of 95%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
2-12-2-deg exhibits increased antiviral potency compared to the parental E inhibitor 2-12-2, with EC90 WT value of 1.67 uM, and 13.27 uM respectively.
2-12-2-deg has a dual mode of action: inhibition of E's function in viral entry and blocking of viral particle production due to a targeted protein degradation (TPD) mechanism.
2-12-2-deg exhibits broad-spectrum activity against multiple flaviviruses, with antiviral EC90 values consistently in the single-digit micromolar across ZIKV, JEV, and WNV Kunjin.
| M.Wt | 860.73 | |
| Formula | C38H34F6N8O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu HY, et al. Nat Commun. 2024 Jun 19;15(1):5179.
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