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2-PCCA

Chemical Structure : 2-PCCA

CAS No.: 1287205-42-8

2-PCCA (GPR88 agonist)

Catalog No.: PC-61115Not For Human Use, Lab Use Only.

2-PCCA is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

2-PCCA is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
2-PCCA inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway.
2-PCCA dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine.
2-PCCA does not alter the behavioral effects of methamphetamine in rats alone.

Physicochemical Properties

M.Wt 455.646
Formula C30H37N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,2R)-N-((2S,3S)-2-amino-3-methylpentyl)-N-(4'-propyl-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide

References

1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7.

2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.

3. Jin C, et al. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.

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