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Chemical Structure : 2-PCCA
CAS No.: 1287205-42-8
Catalog No.: PC-61115Not For Human Use, Lab Use Only.
2-PCCA is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
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| 50 mg | Get quote | ||
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2-PCCA is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
2-PCCA inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway.
2-PCCA dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine.
2-PCCA does not alter the behavioral effects of methamphetamine in rats alone.
| M.Wt | 455.646 | |
| Formula | C30H37N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,2R)-N-((2S,3S)-2-amino-3-methylpentyl)-N-(4'-propyl-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide |
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1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7.
2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.
3. Jin C, et al. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.
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