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Chemical Structure : 2-PCCA hydrochloride
CAS No.: 1609563-71-4
Catalog No.: PC-22286Not For Human Use, Lab Use Only.
2-PCCA hydrochloride is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
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2-PCCA hydrochloride is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
2-PCCA inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway.
2-PCCA dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine.
2-PCCA does not alter the behavioral effects of methamphetamine in rats alone.
| M.Wt | 528.56 | |
| Formula | C30H39Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,2R)-N-((2S,3S)-2-Amino-3-methylpentyl)-N-(4'-propyl-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide dihydrochloride |
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1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7.
2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.
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