You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Carboxypeptidase-2-PMPA
2-PMPA

Chemical Structure : 2-PMPA

CAS No.: 173039-10-6

2-PMPA (2-(Phosphonomethyl)pentanedioic acid)

Catalog No.: PC-42256Not For Human Use, Lab Use Only.

2-PMPA is a potent and selective NAALADase (Glutamate carboxypeptidase II, GCPII/PSMA) inhibitor with Ki of 280 pM.

Packing Price Stock Quantity
5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $298 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

2-PMPA is a potent and selective NAALADase (Glutamate carboxypeptidase II, GCPII/PSMA) inhibitor with Ki of 280 pM.
2-PMPA has no substantial activity against NMDA, AMPA, mGluRs, and glutamate transporters.
2-PMPA potently inhibits oxidative metabolism and glycolysis with IC50 of 617 pM in rat cortical cultures.
2-PMPA robustly protects against ischemic injury in a neuronal culture model of stroke and in rats after transient middle cerebral artery occlusion, increases NAAG and attenuates the ischemia-induced rise in glutamate.

Physicochemical Properties

M.Wt 226.1211
Formula C6H11O7P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 28 mg/mL

Chemical Name/SMILES

Pentanedioic acid, 2-(phosphonomethyl)-

References

1. Slusher BS, et al. Nat Med. 1999 Dec;5(12):1396-402.

2. Thomas AG, et al. Brain Res. 1999 Oct 2;843(1-2):48-52.

3. Tortella FC, et al. Eur J Pharmacol. 2000 Aug 18;402(1-2):31-7.

4. Harada C, et al. Neurosci Lett. 2000 Oct 6;292(2):134-6.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: