2′3′-cGAMP |CAS:1441190-66-4 Probechem Biochemicals

Chemical Structure : 2 3-cGAMP

CAS No.: 1441190-66-4

2 3-cGAMP (2'-3'-Cyclic GMP-AMP, 2′3′-cGAMP)

Catalog No.: PC-62660Not For Human Use, Lab Use Only.

2′3′-cGAMP is a potent STING activator that binds to STING with Kd of 1.61 uM.

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Biological Activity

2′3′-cGAMP is a potent STING activator that binds to STING with Kd of 1.61 uM.
The Kd of 2′3′-cGAMP is ~300 fold lower than those of c-di-GMP, 3′2′-cGAMP and 3′3′-cGAMP, and ~75 fold lower than that of 2′2′-cGAMP。
2′3′-cGAMP a potent inducer of IFNβ in cells (EC50 ~ 20 nM).

Physicochemical Properties

M.Wt	674.41
Formula	C20H24N10O13P2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Amino-9-((5R,7R,8R,12aR,14R,15R,15aS)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxy-2,10-dioxidooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11]pentaoxa[2,10]diphosphacyclotetradecin-7-yl)-3,9-dihydro-6H-purin-6-one

References

1. Zhang X, et al. Mol Cell. 2013 Jul 25;51(2):226-35.

2. Li L, et al. Nat Chem Biol. 2014 Dec;10(12):1043-8.

3. Shi H, et al. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8947-52.

2 3-cGAMP (2'-3'-Cyclic GMP-AMP, 2′3′-cGAMP)

Biological Activity

Physicochemical Properties

References

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