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25B-NBOMe

Chemical Structure : 25B-NBOMe

CAS No.: 1026511-90-9

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25B-NBOMe

Catalog No.: PC-21178Not For Human Use, Lab Use Only.

25B-NBOMe is a highly selective 5-HT2A receptor agonist with Ki of 0.05 nM, 100-fold selective over 5-HT2C (Ki=4.6 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

25B-NBOMe is a highly selective 5-HT2A receptor agonist with Ki of 0.05 nM, 100-fold selective over 5-HT2C (Ki=4.6 nM).
25B-NBOMe also has moderate affinity for the serotonin transporter (SERT, Ki=840 nM) and dopamine D2 receptors (Ki=840 nM), but its affinity for dopamine D1 receptor and dopamine transporter (DAT) is low.
25B-NBOMe in repeated doses induces tolerance in neurotransmitter release.
25B-NBOMe promotes anxiety in rats, shows genotoxic potential and increase in glial cells number.

Physicochemical Properties

M.Wt 380.28
Formula C18H22BrNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine

References

1. Adam Wojtas, et al. Neuropharmacology. 2023 Sep 7;109713.

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