25CN-NBOH | 5-HT2A agonist | Probechem Biochemicals

Chemical Structure : 25CN-NBOH

25CN-NBOH (25CN NBOH)

Catalog No.: PC-60813Not For Human Use, Lab Use Only.

25CN-NBOH is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin).

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Biological Activity

25CN-NBOH is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin).
25CN-NBOH has >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR.
25CN-NBOH exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays.
25CN-NBOH is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).

Physicochemical Properties

M.Wt	312.369
Formula	C18H20N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol

References

1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.

2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.

3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375.

4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.

25CN-NBOH (25CN NBOH)

Biological Activity

Physicochemical Properties

References

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