Chemical Structure : 25CN-NBOH hydrochloride
CAS No.:
1539266-32-4
25CN-NBOH hydrochloride
Catalog No.: PC-28049Not For Human Use, Lab Use Only.
25CN-NBOH hydrochloride is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
25CN-NBOH hydrochloride is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin).
25CN-NBOH has >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR.
25CN-NBOH exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays.
25CN-NBOH is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).
Physicochemical Properties
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M.Wt
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348.83
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Formula
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C18H21ClN2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol hydrochloride
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References
1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.
2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.
3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375.
4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.
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