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28NH

Chemical Structure : 28NH

CAS No.: 1082816-22-5

28NH (TREK channel inhibitor)

Catalog No.: PC-60943Not For Human Use, Lab Use Only.

28NH is a small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    28NH is a small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively.

    Physicochemical Properties

    M.Wt 300.786
    Formula C17H17ClN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-((4-chlorophenyl)amino)-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethanone

    References

    1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378.

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