Catalog No.: PC-36005Not For Human Use, Lab Use Only.
2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays.
2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small moleculeeIF2B activator with EC50 of 33 nM in cell-based reporter assays.
2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice.
2BAct also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice.
