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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Calcium Channel -2G272
2G272

Chemical Structure : 2G272

CAS No.: 3006799-83-0

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2G272

Catalog No.: PC-26379Not For Human Use, Lab Use Only.

2G272 is a smll molecule calcium (Ca2+) influx inducer, triggers store-operated Ca2+ entry (SOCE) in mBMDC as well as increases in CD80 and CD86 surface expression.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

2G272 is a smll molecule calcium (Ca2+) influx inducer, triggers store-operated Ca2+ entry (SOCE) in mBMDC as well as increases in CD80 and CD86 surface expression.
2G272 enhances antigen presenting cell stimulated T cell proliferation.
2G272 promotes the release of immune-stimulatory EVs from mBMDCs. 2G272 does not stimulate systemic cytokine release in vivo.
2G272 elicits Th2 biased immune responses in a murine model.

Physicochemical Properties

M.Wt 444.38
Formula C15H15N3O4S2Se
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 2-(benzo[c][1,2,5]selenadiazole-4-sulfonamido)-4,5-dimethylthiophene-3-carboxylate

References

1. Yokoyama Y, et al. Front Immunol. 2026 Feb 17;17:1704416.

2. Sako Y, et al. ACS Chem Biol. (2023) 18:982–93.

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