Chemical Structure : 2GBI
CAS No.: 5418-95-1
Catalog No.: PC-38295Not For Human Use, Lab Use Only.
2GBI (2-guanidinobenzimidazole) is a guanidine derivative that inhibits voltage-gated proton channel Hv1 by binding to the VSD from its intracellular side..
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2GBI (2-guanidinobenzimidazole) is a guanidine derivative that inhibits voltage-gated proton channel Hv1 by binding to the VSD from its intracellular side.
2GBI also is an agonist directly targeting NLRP3, induces inflammasome activation, which is independent of potassium efflux, chloride efflux and mitochondrial dysfunction.
M.Wt | 175.195 | |
Formula | C8H9N5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-guanidinobenzimidazole |
1. Hong L, et al. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9971-6.
2. Gianti E, et al. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8359-E8368.
3. Geragotelis AD, et al. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13490-13498.
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