A glycolytic inhibitor that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress; potentiates acetate-induced apoptosis and anti-proliferative effect in CRC cells; abrogates MUC1-mediated radiation resistance both in vitro and in vivo pancreatic cancer models, by reducing glucose flux into nucleotide biosynthetic pathways and enhancing DNA damage.
Physicochemical Properties
M.Wt
166.9581
Formula
C3H3BrO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 32 mg/mL
Chemical Name/SMILES
Propanoic acid, 3-bromo-2-oxo-
References
1. Can Z, et al. Anticancer Drugs. 2017 Aug;28(7):739-749.
