Chemical Structure : 3-Hydroxykynurenine
CAS No.:
606-14-4
3-Hydroxykynurenine
(3-HK, 3-Hydroxy-L-kynurenine)
Catalog No.: PC-22609Not For Human Use, Lab Use Only.
3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses.
3-HK disrupts the host–pathogen dynamic to promote survival.
Endogenous production of 3-HK is required for host defense.
3-HK does not act via known kynurenine pathway mechanisms.
3-HK upregulates iGluRs of the AMPA and KAR subclasses.
3-HK promotes survival from lethal bacterial infection by inhibiting bacterial expansion in macrophages.
Physicochemical Properties
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M.Wt
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224.22
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Formula
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C10H12N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
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References
1. Parada-Kusz M, et al. Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z.
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