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Chemical Structure : 3-Hydroxykynurenine
Catalog No.: PC-22609Not For Human Use, Lab Use Only.
3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses.
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3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses.
3-HK disrupts the host–pathogen dynamic to promote survival.
Endogenous production of 3-HK is required for host defense.
3-HK does not act via known kynurenine pathway mechanisms.
3-HK upregulates iGluRs of the AMPA and KAR subclasses.
3-HK promotes survival from lethal bacterial infection by inhibiting bacterial expansion in macrophages.
| M.Wt | 224.22 | |
| Formula | C10H12N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Parada-Kusz M, et al. Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z.
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