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Chemical Structure : 3i-1000
CAS No.: 544681-96-1
Catalog No.: PC-63247Not For Human Use, Lab Use Only.
3i-1000 is a potent, small molecule inhibitor of GATA4-NKX2-5 interaction, inhibits GATA4-NKX2-5 transcriptional synergy with IC50 of 3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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3i-1000 is a potent, small molecule inhibitor of GATA4-NKX2-5 interaction, inhibits GATA4-NKX2-5 transcriptional synergy with IC50 of 3 uM.
3i-1000 inhibits cardiac gene expression induced by mechanical stretch and phenylephrine, such as ANP and BNP, without significantly influencing the baseline mRNA levels, inhibits hypertrophic process in cardiomyocytes in vitro.
3i-1000 significantly inhibits PE-induced elevation in GATA4 Ser-105 phosphorylation in neonatal rat cardiomyocytes.
3i-1000 promotes myocardial repair in experimental model of myocardial ischemia reperfusion injury.
| M.Wt | 349.434 | |
| Formula | C21H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide |
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1. Kinnunen SM, et al. Sci Rep. 2018 Mar 15;8(1):4611.
2. Välimäki MJ, et al. J Med Chem. 2017 Sep 28;60(18):7781-7798.
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