Chemical Structure : 3i-1262
CAS No.:
3i-1262
(3i 1262)
Catalog No.: PC-21677Not For Human Use, Lab Use Only.
3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.
3i-1262 is a more potent inhibitor (64% vs. 38%, synergy of GATA4 and NKX2-5 inhibition) than 3i-1000.
3i-1262 (30 uM) significantly attenuates ET-1-induced BNP activation in neonatal rat ventricular myocytes (NRVMs), significantly inhibits stretch-induced NPPB gene expression.
3i-1262 induces cardiomyocyte metabolic processes and attenuates cell cycle processes in hiPSC-CMs.
3i-1262 induces maturation-related gene expression in hiPSC-CMs.
3i-1262 reorganises the cardiac TF network and converts hypertrophic signalling towards enhanced cardiomyocyte specification and maturity.
Physicochemical Properties
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M.Wt
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392.46
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Formula
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C22H24N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-Benzamido-N-[4-(diethylamino)phenyl]-3- methylisoxazole-4-carboxamide
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References
1. Lotta Pohjolainen, et al. Stem Cell Res Ther. 2024 Jan 2;15(1):5.
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