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Chemical Structure : 3i-1262
Catalog No.: PC-21677Not For Human Use, Lab Use Only.
3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.
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3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.
3i-1262 is a more potent inhibitor (64% vs. 38%, synergy of GATA4 and NKX2-5 inhibition) than 3i-1000.
3i-1262 (30 uM) significantly attenuates ET-1-induced BNP activation in neonatal rat ventricular myocytes (NRVMs), significantly inhibits stretch-induced NPPB gene expression.
3i-1262 induces cardiomyocyte metabolic processes and attenuates cell cycle processes in hiPSC-CMs.
3i-1262 induces maturation-related gene expression in hiPSC-CMs.
3i-1262 reorganises the cardiac TF network and converts hypertrophic signalling towards enhanced cardiomyocyte specification and maturity.
| M.Wt | 392.46 | |
| Formula | C22H24N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lotta Pohjolainen, et al. Stem Cell Res Ther. 2024 Jan 2;15(1):5.
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