Chemical Structure : 4-OH-DiPT
CAS No.:
132328-45-1
4-OH-DiPT
Catalog No.: PC-22529Not For Human Use, Lab Use Only.
4-OH-DiPT is a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM, shows strongest agonist activity at all three 5-HT2A/2B/2C receptors with near full agonist activity at 5-HT2A.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
4-OH-DiPT is a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM, shows strongest agonist activity at all three 5-HT2A/2B/2C receptors with near full agonist activity at 5-HT2A.
4-OH-DiPT has comparable activity at mouse and human 5-HT2A/2B/2C receptors.
4-OH-DiPT significantly reduced freezing responses to conditioned cues in a dose-dependent manner with a greater potency in female mice than male mice.
4-OH-DiPT activates BLA interneurons via the 5-HT2A receptor to enhance GABAergic inhibition of BLA principal neurons.
Physicochemical Properties
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M.Wt
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260.38
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Formula
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C16H24N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-hydroxy-N,N-diisopropyltryptamine
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References
1. Kelly TJ, et al. Neuropsychopharmacology. 2024 Apr;49(5):854-863.
2. Bryson N, et al. ACS Chem Neurosci. 2024 May 17. doi: 10.1021/acschemneuro.4c00058.
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