Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : 4-OH-DiPT
Catalog No.: PC-22529Not For Human Use, Lab Use Only.
4-OH-DiPT is a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM, shows strongest agonist activity at all three 5-HT2A/2B/2C receptors with near full agonist activity at 5-HT2A.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
4-OH-DiPT is a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM, shows strongest agonist activity at all three 5-HT2A/2B/2C receptors with near full agonist activity at 5-HT2A.
4-OH-DiPT has comparable activity at mouse and human 5-HT2A/2B/2C receptors.
4-OH-DiPT significantly reduced freezing responses to conditioned cues in a dose-dependent manner with a greater potency in female mice than male mice.
4-OH-DiPT activates BLA interneurons via the 5-HT2A receptor to enhance GABAergic inhibition of BLA principal neurons.
| M.Wt | 260.38 | |
| Formula | C16H24N2O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kelly TJ, et al. Neuropsychopharmacology. 2024 Apr;49(5):854-863.
2. Bryson N, et al. ACS Chem Neurosci. 2024 May 17. doi: 10.1021/acschemneuro.4c00058.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
