Chemical Structure : 4-PQBH
CAS No.:
2765240-30-8
4-PQBH
(4 PQBH)
Catalog No.: PC-21508Not For Human Use, Lab Use Only.
4-PQBH is a small molecule Nur77-mediated cytoplasmic vacuolation and paraptosis inducer, binds to Nur77 (KD=1.17 uM) and shows potentially selective cytotoxicity to HCC cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
4-PQBH is a small molecule Nur77-mediated cytoplasmic vacuolation and paraptosis inducer, binds to Nur77 (KD=1.17 uM) and shows potentially selective cytotoxicity to HCC cells.
4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy.
4-PQBH exhibits potent anti-HCC activity (HepG2 cells, IC50=2.6 uM) and is low toxic to normal LO2 cells (IC50=17.32 uM).
4-PQBH effectively inhibits tumor growth in HepG2 xenografted model in immunodeficient mice.
4-PQBH targets Nur77 to endoplasmic reticulum (ER) and induces Nur77-mediated ER stress as well as autophagy, resulting in cytoplasmic vacuolation and paraptosis-like cell death.
Physicochemical Properties
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M.Wt
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367.41
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Formula
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C22H17N5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N'-(pyridin-4-ylmethylene)-4-(quinolin-4-ylamino)benzohydrazide
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References
1. Baicun Li, et al. Bioorg Chem. 2022 Apr:121:105651.
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