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Chemical Structure : 4-PQBH
Catalog No.: PC-21508Not For Human Use, Lab Use Only.
4-PQBH is a small molecule Nur77-mediated cytoplasmic vacuolation and paraptosis inducer, binds to Nur77 (KD=1.17 uM) and shows potentially selective cytotoxicity to HCC cells.
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4-PQBH is a small molecule Nur77-mediated cytoplasmic vacuolation and paraptosis inducer, binds to Nur77 (KD=1.17 uM) and shows potentially selective cytotoxicity to HCC cells.
4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy.
4-PQBH exhibits potent anti-HCC activity (HepG2 cells, IC50=2.6 uM) and is low toxic to normal LO2 cells (IC50=17.32 uM).
4-PQBH effectively inhibits tumor growth in HepG2 xenografted model in immunodeficient mice.
4-PQBH targets Nur77 to endoplasmic reticulum (ER) and induces Nur77-mediated ER stress as well as autophagy, resulting in cytoplasmic vacuolation and paraptosis-like cell death.
| M.Wt | 367.41 | |
| Formula | C22H17N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Baicun Li, et al. Bioorg Chem. 2022 Apr:121:105651.
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