Catalog No.: PC-38475Not For Human Use, Lab Use Only.
4BP-TQS (GAT107 racemic) is a potent, selective, allosteric agonist of α7 nAChRs with EC50 of 17 uM, no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 uM.
4BP-TQS (GAT107 racemic) is a potent, selective, allosteric agonist of α7 nAChRs with EC50 of 17 uM, no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 uM.
Metyllycaconitine is a noncompetitive antagonist of 4BP-TQS.
Mutation of an amino acid (M253L), located in a transmembrane cavity, completely blocks agonist activation by 4BP-TQS.
4BP-TQS acts as potentiator of acetylcholine responses, facilitates recovery of α7 nAChRs from desensitization.
