Chemical Structure : 4L2-P13D
CAS No.:
4L2-P13D
Catalog No.: PC-25547Not For Human Use, Lab Use Only.
4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo.
Physicochemical Properties
|
M.Wt
|
1859.13
|
|
Formula
|
C89H123N19O23S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
[H]N1[C@@H](CC2=CC=C(C=C2)O)C(N[C@H](C(N[C@]([H])(C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@]([H])(C(N[C@@H](CC6=CC=CC=C6)C(N[C@]([H])(C(N[C@@H](C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CSCC1=O)C(NCC(N)=O)=O)=O)=O)CC(C)C)=O)=O)[C@H](CC)C)=O)=O)[C@@H](C)O)=O)=O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O
|
References
1. ChunMei An, et al. J Med Chem. 2025 Sep 18. doi: 10.1021/acs.jmedchem.5c01432.
Contact Us
sales@probechem.com
