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5-HT2A agonist (R)-70

Chemical Structure : 5-HT2A agonist (R)-70

CAS No.: 2765652-36-4

5-HT2A agonist (R)-70

Catalog No.: PC-49806Not For Human Use, Lab Use Only.

5-HT2A agonist (R)-70 is a potent selective 5-HT2A receptor partial agonist with EC50 of 110 nM in calcium flux assays, and Ki value of 880 nM.

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    Biological Activity

    5-HT2A agonist (R)-70 is a potent selective 5-HT2A receptor partial agonist with EC50 of 110 nM in calcium flux assays, and Ki value of 880 nM.
    (R)-70 has an agonist EC50 of 700  nM versus 5-HT2BR, 6.4-fold selective for the 5-HT2AR, and >30-fold selectivity over 5-HT2AC.
    (R)-70 is inactive versus the serotonin transporter SERT DAT or NET transporters.
    (R)-70 does not possess locomotor-stimulating or reinforcing activity, exerts no effects on prepulse inhibition (PPI) relative to LSD.
    (R)-70 demonstrates anxiolytic-like and strong antidepressant drug-like effects in mouse models.

    Physicochemical Properties

    M.Wt 227.31
    Formula C14H17N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-3-(1,5-dimethyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

    References

    1. Kaplan AL, et al. Nature. 2022 Oct;610(7932):582-591.

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