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Chemical Structure : 5-HT2A agonist (R)-70
Catalog No.: PC-49806Not For Human Use, Lab Use Only.
5-HT2A agonist (R)-70 is a potent selective 5-HT2A receptor partial agonist with EC50 of 110 nM in calcium flux assays, and Ki value of 880 nM.
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5-HT2A agonist (R)-70 is a potent selective 5-HT2A receptor partial agonist with EC50 of 110 nM in calcium flux assays, and Ki value of 880 nM.
(R)-70 has an agonist EC50 of 700 nM versus 5-HT2BR, 6.4-fold selective for the 5-HT2AR, and >30-fold selectivity over 5-HT2AC.
(R)-70 is inactive versus the serotonin transporter SERT DAT or NET transporters.
(R)-70 does not possess locomotor-stimulating or reinforcing activity, exerts no effects on prepulse inhibition (PPI) relative to LSD.
(R)-70 demonstrates anxiolytic-like and strong antidepressant drug-like effects in mouse models.
| M.Wt | 227.31 | |
| Formula | C14H17N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaplan AL, et al. Nature. 2022 Oct;610(7932):582-591.
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