Chemical Structure : 5-HT2A antagonist 11c
CAS No.:
2641482-08-6
5-HT2A antagonist 11c
Catalog No.: PC-21787Not For Human Use, Lab Use Only.
5-HT2A antagonist 11c is a potent, selective, peripheral 5HT2A antagonist with IC50 of 14 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
5-HT2A antagonist 11c is a potent, selective, peripheral 5HT2A antagonist with IC50 of 14 nM.
5-HT2A antagonist 11c shows good chemical, hepatocyte, and plasma stability, no significant cytotoxicity in five representative mammalian cell lines (VERO, HFL-1, L929, NIH3T3, CHO-K1).
5-HT2A antagonist 11c shows selective inhibition of 5HT2A among other 5-HT subtypes.
5-HT2A antagonist 11c (5 and 10 mpk) daily oral gavage attenuates HFD-induced obesity, MASLD, and metabolic syndrome.
5-HT2A antagonist 11c shows vivo efficacy against CDAHFD-induced liver fibrosis and inflammation C57BL/6 J mice.
5-HT2A antagonist 11c is a novel peripheral 5HT2A antagonist for Metabolic Dysfunction-Associated Steatohepatitis (MASH) and steatosis under clinical investigations.
Physicochemical Properties
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M.Wt
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517.07
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Formula
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C30H33ClN4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(2-(4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
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References
1. Haushabhau S Pagire, et al. Nat Commun. 2024 Jan 20;15(1):645.
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