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Chemical Structure : 5-HT6 receptor antagonist 15
Catalog No.: PC-21666Not For Human Use, Lab Use Only.
5-HT6 receptor antagonist 15 is a first-in-class, selenium containing, highly potent and selective 5-HT6R antagonist with Ki of 14 nM.
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5-HT6 receptor antagonist 15 is a first-in-class, selenium containing, highly potent and selective 5-HT6R antagonist with Ki of 14 nM.
5-HT6 receptor antagonist 15 demonstrated neuroprotection against rotenone-induced neurotoxicity as well as antioxidant and glutathione peroxidase (GPx)-like activity and regulated antioxidant and pro-inflammatory genes and NRF2 nuclear translocation.
5-HT6 receptor antagonist 15 showed satisfying pharmacokinetics, penetrated the blood–brain barrier, reversed MK-801-induced memory impairment, and exhibited anxiolytic-like properties.
| M.Wt | 441.44 | |
| Formula | C21H26N6Se | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pyka P, et al. J Med Chem. 2024 Jan 8. doi: 10.1021/acs.jmedchem.3c02148.
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