Chemical Structure : 5-HT6 receptor antagonist 15
CAS No.:
5-HT6 receptor antagonist 15
Catalog No.: PC-21666Not For Human Use, Lab Use Only.
5-HT6 receptor antagonist 15 is a first-in-class, selenium containing, highly potent and selective 5-HT6R antagonist with Ki of 14 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
5-HT6 receptor antagonist 15 is a first-in-class, selenium containing, highly potent and selective 5-HT6R antagonist with Ki of 14 nM.
5-HT6 receptor antagonist 15 demonstrated neuroprotection against rotenone-induced neurotoxicity as well as antioxidant and glutathione peroxidase (GPx)-like activity and regulated antioxidant and pro-inflammatory genes and NRF2 nuclear translocation.
5-HT6 receptor antagonist 15 showed satisfying pharmacokinetics, penetrated the blood–brain barrier, reversed MK-801-induced memory impairment, and exhibited anxiolytic-like properties.
Physicochemical Properties
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M.Wt
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441.44
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Formula
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C21H26N6Se
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(4-methylpiperazin-1-yl)-6-((2-(naphthalen-2-yl)propan-2-yl)selanyl)-1,3,5-triazin-2-amine
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References
1. Pyka P, et al. J Med Chem. 2024 Jan 8. doi: 10.1021/acs.jmedchem.3c02148.
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