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5-Iodotubercidin

Chemical Structure : 5-Iodotubercidin

CAS No.: 24386–93-4

5-Iodotubercidin (5-ITU, 5-IT, NSC 113939)

Catalog No.: PC-38793Not For Human Use, Lab Use Only.

5-Iodotubercidin (5-ITU) is a potent adenosine kinase (AdK) inhibitor with IC50 of 26 nM, also potently inhibits SARS-CoV-2 RNA synthesis.

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Biological Activity

5-Iodotubercidin (5-ITU) is a potent adenosine kinase (AdK) inhibitor with IC50 of 26 nM, also potently inhibits SARS-CoV-2 RNA synthesis.

Physicochemical Properties

M.Wt 392.15
Formula C11H13IN4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

References

1. Massillon D, et al. Biochem J. 1994 Apr 1;299 (Pt 1):123-8.

2. Ugarkar BG, et al. J Med Chem. 2000 Jul 27;43(15):2883-93.

3. García-Villafranca J, et al. Biochem Pharmacol. 2002 Jun 1;63(11):1997-2000.

4. Zhao J, et al. Antiviral Res. 2022 Feb;198:105254.

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