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Chemical Structure : 5-NIdR
CAS No.: 191421-10-0
Catalog No.: PC-62750Not For Human Use, Lab Use Only.
5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.
5-NIdR efficiently and selectively inhibits the replication of DNA lesions, synergizes with temozolomide to increase apoptosis of tumor cells.
5-NIdR causes complete tumor regression combined with Temozolomide in murine xenograft model of glioblastoma
| M.Wt | 278.264 | |
| Formula | C13H14N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2R,3R,5R)-2-(hydroxymethyl)-5-(5-nitro-1H-indol-1-yl)tetrahydrofuran-3-ol |
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1. Choi JS, et al. Cancer Res. 2018 Feb 15;78(4):1083-1096.
2. Ahmad MF, et al. Mol Cancer Ther. 2012 Oct;11(10):2077-86.
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