You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-5-NIdR
5-NIdR

Chemical Structure : 5-NIdR

CAS No.: 191421-10-0

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside)

Catalog No.: PC-62750Not For Human Use, Lab Use Only.

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.

Packing Price Stock Quantity
10 mg $138 In stock
25 mg $258 In stock
50 mg $428 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.
5-NIdR efficiently and selectively inhibits the replication of DNA lesions, synergizes with temozolomide to increase apoptosis of tumor cells.
5-NIdR causes complete tumor regression combined with Temozolomide in murine xenograft model of glioblastoma

Physicochemical Properties

M.Wt 278.264
Formula C13H14N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3R,5R)-2-(hydroxymethyl)-5-(5-nitro-1H-indol-1-yl)tetrahydrofuran-3-ol

References

1. Choi JS, et al. Cancer Res. 2018 Feb 15;78(4):1083-1096.

2. Ahmad MF, et al. Mol Cancer Ther. 2012 Oct;11(10):2077-86.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: