5F-203 (NSC 703786) is a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
5F-203 (NSC 703786) causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription.
L-lysylamide prodrug Phortress (NSC 710305) demonstrats antitumor activity in vivo.
Physicochemical Properties
M.Wt
258.314
Formula
C14H11FN2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole
References
1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605.
4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.
