Catalog No.: PC-61198Not For Human Use, Lab Use Only.
5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
5Z-7-Oxozeaenol inhibits IL-1-induced activation of NF-κB (IC50= 83 nM) and JNK/p38, inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
5Z-7-Oxozeaenol significantly enhances chemotherapeutic efficacy in vivo.
