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Chemical Structure : 5Z-7-Oxozeaenol
CAS No.: 253863-19-3
Catalog No.: PC-61198Not For Human Use, Lab Use Only.
5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $298 | In stock | |
| 5 mg | $558 | In stock | |
| 10 mg | $898 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
5Z-7-Oxozeaenol inhibits IL-1-induced activation of NF-κB (IC50= 83 nM) and JNK/p38, inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
5Z-7-Oxozeaenol significantly enhances chemotherapeutic efficacy in vivo.
| M.Wt | 362.37 | |
| Formula | C19H22O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione |
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1. Ninomiya-Tsuji J, et al. J Biol Chem. 2003 May 16;278(20):18485-90.
2. Choo MK, et al. Mol Cancer Ther. 2006 Dec;5(12):2970-6.
3. Sogabe Y, et al. Bioorg Med Chem Lett. 2015 Feb 1;25(3):593-6.
4. Fan Y, et al. Apoptosis. 2013 Oct;18(10):1224-34.
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