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Chemical Structure : 6-B345TTQ
Catalog No.: PC-49780Not For Human Use, Lab Use Only.
6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration.
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6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration.
6-B345TTQ did not inhibited the interaction of leupaxin with the FAT sequence of pp125FAK at 100 uM.
6-B345TTQ inhibited α4-mediated monocyte and T cell migration by 52.6% and 56.4%, respectively, but did not significantly reduce T cell migration mediated by other α integrin subunits.
6-B345TTQ inhibited the interaction of paxillin with FAT and Git-1 (IC50=24 uM).
6-B345TTQ (40 uM) increases α4-dependent cell spreading in Jurkat T cells and CHO cells.
6-B345TTQ (16.5 mg/kg, sterile 4% (w/v) thioglycollate, i.p.) impaired the recruitment of mononuclear leukocytes to the peritoneum in response to thioglycollate in C57BL/6 mice.
| M.Wt | 442.31 | |
| Formula | C22H20BrNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kummer C, et al. J Biol Chem. 2010 Mar 26;285(13):9462-9469.
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