Catalog No.: PC-49780Not For Human Use, Lab Use Only.
6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration.
6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration.
6-B345TTQ did not inhibited the interaction of leupaxin with the FAT sequence of pp125FAK at 100 uM.
6-B345TTQ inhibited α4-mediated monocyte and T cell migration by 52.6% and 56.4%, respectively, but did not significantly reduce T cell migration mediated by other α integrin subunits.
6-B345TTQ inhibited the interaction of paxillin with FAT and Git-1 (IC50=24 uM).
6-B345TTQ (40 uM) increases α4-dependent cell spreading in Jurkat T cells and CHO cells.
6-B345TTQ (16.5 mg/kg, sterile 4% (w/v) thioglycollate, i.p.) impaired the recruitment of mononuclear leukocytes to the peritoneum in response to thioglycollate in C57BL/6 mice.
