Chemical Structure : 6-Ethylthioinosine
CAS No.:
13286-04-9
6-Ethylthioinosine
(6-ETI;NSC 39368;SRI 1215)
Catalog No.: PC-61684Not For Human Use, Lab Use Only.
6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines.
6-Ethylthioinosine (6-ETI) has LC50 of 30-435 nM against KSHV+ PEL cell lines, and inhibits NF-κB in PELs at 10-50 uM.
6-Ethylthioinosine (6-ETI) requires adenosine kinase (ADK) to phosphorylate and activate 6-ETI.
6-Ethylthioinosine (6-ETI) induces ATP depletion and cell death accompanied by S phase arrest and DNA damage only in ADK-expressing cells.
6-Ethylthioinosine (6-ETI) shows a robust antitumor effect in a disseminated MM mouse model.
Physicochemical Properties
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M.Wt
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312.344
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Formula
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C12H16N4O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,3R,4R,5R)-2-(6-ethylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
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References
1. Nayar U, et al. J Clin Invest. 2017 Jun 1;127(6):2066-2080.
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