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Chemical Structure : 6-Ethylthioinosine
Catalog No.: PC-61684Not For Human Use, Lab Use Only.
6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines.
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6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines.
6-Ethylthioinosine (6-ETI) has LC50 of 30-435 nM against KSHV+ PEL cell lines, and inhibits NF-κB in PELs at 10-50 uM.
6-Ethylthioinosine (6-ETI) requires adenosine kinase (ADK) to phosphorylate and activate 6-ETI.
6-Ethylthioinosine (6-ETI) induces ATP depletion and cell death accompanied by S phase arrest and DNA damage only in ADK-expressing cells.
6-Ethylthioinosine (6-ETI) shows a robust antitumor effect in a disseminated MM mouse model.
| M.Wt | 312.344 | |
| Formula | C12H16N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nayar U, et al. J Clin Invest. 2017 Jun 1;127(6):2066-2080.
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