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6-MOMIPP

Chemical Structure : 6-MOMIPP

CAS No.: 1961272-45-6

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6-MOMIPP

Catalog No.: PC-35822Not For Human Use, Lab Use Only.

6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.
    6-MOMIPP demonstrates broad activity against the viability of multiple glioblastoma, melanoma and lung carcinoma cell lines.
    6-MOMIPP effectively inhibits growth of subcutaneous and intracerebral tumors without causing general toxicity in mice bearing human U251 glioblastoma xenografts .

    Physicochemical Properties

    M.Wt 292.338
    Formula C18H16N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(6-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one

    References

    1. Du S, et al. Cancer Chemother Pharmacol. 2018 Nov 13. doi: 10.1007/s00280-018-3726-1.

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