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6-alkynyl Fucose

Chemical Structure : 6-alkynyl Fucose

CAS No.: 935658-91-6

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6-alkynyl Fucose (Notch1 inhibitor fucose analog)

Catalog No.: PC-60004Not For Human Use, Lab Use Only.

6-alkynyl Fucose is a fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    6-alkynyl Fucose is a fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.
    6-alkynyl Fucose is the substrate of protein O-fucosyltransferase 1 (Pofut1), incorporates into EGF8 of Notch1 and markedly reduces the ability of Delta ligands to bind and activate Notch1.
    6-alkynyl Fucose inhibits Notch signaling in Zebrafish.

    Physicochemical Properties

    M.Wt 342.3
    Formula C15H18O9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,4R,5R,6S)-6-ethynyltetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

    References

    1. Schneider M, et al. Nat Chem Biol. 2017 Nov 27.

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