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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Tryptophan 2,3-Dioxygenase (TDO)-680C91
680C91

Chemical Structure : 680C91

CAS No.: 163239-22-3

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680C91 (TDO2 inhibitor 680C91)

Catalog No.: PC-49666Not For Human Use, Lab Use Only.

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) with Ki of 51 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) with Ki of 51 nM.
680C91 displays no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors.
680C91 produces large increases in brain tryptophan and serotonin in vitro and in vivo in rats.

Physicochemical Properties

M.Wt 238.27
Formula C15H11FN2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1H-indole

References

1. Salter M, et al. Neuropharmacology. 1995 Feb;34(2):217-27.

2. Salter M, et al. Biochem Pharmacol. 1995 May 17;49(10):1435-42.

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